NUCALA is indicated for the add-on maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adult patients 18 years of age and older with inadequate response to nasal corticosteroids.

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Also choose NUCALA for improving quality of life, based on SNOT-22

In the SYNAPSE study, all primary and secondary endpoints were met with statistical significance.1


Co-primary endpoints:

Significant improvement in nasal polyp size. LS mean§ change from baseline in total endoscopic nasal polyp score at Week 52: NUCALA + SOC|| (n=206), –0.87 (baseline score: 5.4) vs placebo + SOC|| (n=201), 0.06 (baseline score: 5.6); P<0.001.1,2

Significant improvement in nasal obstruction. LS mean§ change from baseline in nasal obstruction VAS score at Weeks 49-52: NUCALA + SOC|| (n=206), –4.40 (baseline score: 8.9) vs placebo + SOC|| (n=201), –2.54 (baseline score: 9.0); P<0.001.1,2

Key secondary endpoint: Time to next nasal polyp surgery up to Week 52: 57% reduction in the proportion of patients who had surgery with NUCALA + SOC vs placebo + SOC, HR: 0.43; P=0.0032.1

Secondary endpoint: Median change from baseline in SNOT-22 total score at Week 52; NUCALA + SOC, 30-point improvement vs placebo + SOC, 14-point improvement; P=0.0032.1

LS means from analysis using mixed model repeated measures.

Defined as daily mometasone furoate nasal spray in addition to saline nasal irrigations and courses of systemic corticosteroids and/or antibiotics as required.

HR=hazard ratio; IL=interleukin; LS=least squares; SNOT-22=sino-nasal outcome test (22-item); SOC=standard of care; VAS=visual analogue scale.

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NUCALA is the only anti-IL-5 approved for CRSwNP

See other indications for eosinophil-driven diseases

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Get your patients started with NUCALA

Steps for accessing NUCALA and other helpful resources for your nasal polyp patients and practice.

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Administering NUCALA

NUCALA gives appropriate patients the option to self-administer at home.