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NUCALA—the only anti-IL-5
therapy for HES—provided
proven protection from flares

NUCALA is indicated for the treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause.

Choose NUCALA for HES

Choose NUCALA for HES

Proven protection from flares in a

randomized, placebo-controlled trial1


of patients had

ZERO flares vs

44% with placebo

Results are descriptive.

Primary endpoint results: Proportion of patients who experienced HES flare(s)* during the 32-week study or withdrew. NUCALA 28% vs placebo 56%, P=0.002.

*HES flare: Worsening of clinical signs/symptoms or increased eosinophils (on ≥2 occasions), resulting in an escalation/addition of oral corticosteroids (OCS) or cytotoxic or immunosuppressive therapy.

Identifying hypereosinophilic syndrome (HES)

Identifying HES

The definition, clinical manifestations, and more

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Flare reduction

Proportion of patients with flares and time to first flare

Eosinophil reduction image

Eosinophil reduction and mechanism of action (MOA)

See the results of NUCALA on eosinophil reduction