Nasal polyp patient profiles

Nasal polyp patient profiles

Clinical trial (SYNAPSE) patients had recurrent nasal polyps that qualified for surgery

Select baseline characteristics (N=407)1,2:

Cross icon

All patients had ≥1 prior surgeries
for nasal polyps*

  • 54% of patients had ≥2 prior surgeries
  • Nasal polyp duration for ~11 years
Quality of life icon

Quality of life severely impacted

Mean SNOT-22 score: 64.1 out of 110

Eosinophils icon

Elevated blood eosinophil levels

Geometric mean: 390 cells/µL

Pill icon

48% of patients had ≥1 course of systemic corticosteroids for nasal polyps in past 12 months

Nose icon

Nasal polyp severity consistent with a need for repeat surgery

  • Bilateral NP score: ≥5 out of 8
  • Overall NP symptom score: >7 out of 10
Lung icon

71% of patients had comorbid asthma

Cross icon

All patients had ≥1 prior surgeries
for nasal polyps*

  • 54% of patients had ≥2 prior surgeries
  • Nasal polyp duration for ~11 years
Eosinophils icon

Elevated blood eosinophil levels

Geometric mean: 390 cells/µL

Nose icon

Nasal polyp severity consistent with a
need for repeat surgery

  • Bilateral NP score: ≥5 out of 8
  • Overall NP symptom score: >7 out of 10
Quality of life icon

Quality of life severely impacted

Mean SNOT-22 score: 64.1 out of 110

Pill icon

48% of patients had ≥1 course of systemic corticosteroids for nasal polyps in past 12 months

Lung icon

71% of patients had comorbid asthma

*Defined as any procedure involving instruments resulting in incision and removal of tissue (polypectomy) in the nasal cavity and the sinuses in the past 10 years.2

Based on stratification of SNOT-22 scores severity, with scores >50 = considered "severe."3

NP=nasal polyp; SNOT-22=sino-nasal outcome test (22-item).

PATIENT PROFILE

Recurrent nasal polyps

Recurrent nasal polyps patient profile
Recurrent nasal polyps patient profile

Current complaints & key concerns

  • Nasal obstruction that impacts his sleep, resulting in fatigue
  • Chronic bothersome nasal discharge
  • Reduced sense of smell and taste

Medical history

  • Diagnosed with CRSwNP 5 years ago
  • 1 endoscopic sinus surgery 2 years ago
  • Symptoms returned 6 months ago
  • Received 1 course of OCS in past 6 months

Current nasal polyp medications

  • Intranasal corticosteroid spray twice daily
  • Nasal saline irrigation daily

PATIENT PROFILE

Nasal polyps with comorbid asthma*

Nasal polyps with comorbid asthma patient profile
Nasal polyps with comorbid asthma patient profile

Current complaints & key concerns

  • Nasal congestion symptoms have increased in severity over past 6 months and are affecting her sleep
  • Constant feeling of mucus in her throat
  • Feeling frustrated with her nasal polyp symptoms and worried about the need for repeat surgery

Medical history

  • Diagnosed with nasal polyps 4 years ago
  • Diagnosed with asthma 8 years ago; symptoms persist
  • 1 endoscopic sinus surgery 2 years ago
  • Nasal polyp symptoms returned 1 year ago
  • No history of respiratory reactions to NSAIDs
  • Received OCS burst for CRSwNP 4 months ago

Current nasal polyp medications

  • Intranasal corticosteroid spray twice daily
  • Nasal saline irrigation daily

*NUCALA is for the add-on treatment of patients 6+ with severe eosinophilic asthma. Not for acute bronchospasm or status asthmaticus.

PATIENT PROFILE

Nasal polyps with comorbid AERD

Nasal polyps with comorbid AERD patient profile
Nasal polyps with comorbid AERD patient profile

Current complaints & key concerns

  • Severe nasal obstruction making it difficult to fall asleep
  • Constant post-nasal drip and cough waking him up at night
  • Chronic runny nose leading to frustration and embarrassment
  • Sinus pain and facial discomfort interfering with his ability to concentrate

Medical history

  • Diagnosed with CRSwNP 7 years ago
  • Diagnosed with severe asthma 4 years ago; increased use of rescue inhaler for symptoms
  • Diagnosed with AERD 2 years ago
  • 2 previous endoscopic sinus surgeries
    • Most recent 1 year ago
  • Nasal polyp symptoms returned 6 months ago
  • Finished OCS course for CRSwNP 1 month ago

Current nasal polyp medications

  • Intranasal corticosteroid spray twice daily
  • Nasal saline irrigation daily

AERD=aspirin-exacerbated respiratory disease; NERD=NSAID-exacerbated respiratory disease; NSAID=nonsteroidal anti-inflammatory drug; OCS=oral corticosteroids.