THE NUCALA SAFETY PROFILE IS WELL ESTABLISHED 

A total of 1327 patients ≥12 years of age with severe asthma were evaluated in 3 randomized, placebo-controlled, multicenter trials of 24 to 52 weeks’ duration: Trial 1,* Trial 2, and Trial 3. Approximately 2% of patients receiving NUCALA withdrew from these clinical trials due to adverse events vs 3% of patients receiving placebo.

*Trial 1: 52-week dose-ranging exacerbation study.

NUCALA safety data in severe eosinophilic asthma (SEA)

ADVERSE REACTIONS ≥3% (AND MORE COMMON THAN PLACEBO) 
IN THE FIRST 24 WEEKS OF TRIAL 2 AND TRIAL 3

 NUCALA adverse reactions from the first 24 weeks of Trials 2 and 3 NUCALA adverse reactions from the first 24 weeks of Trials 2 and 3

Patients aged 6 to 11 years: Adverse reaction profile similar to trials in patients aged ≥12 years.

Serious adverse events (SAE): One SAE occurred in >1 patient and more frequently with NUCALA than placebo: herpes zoster (2 vs 0 patients).

Systemic reactions: In the 3 clinical trials, NUCALA 3% and placebo 5%.

  • Manifestations included rash, flushing, pruritus, headache, and myalgia. A majority were experienced on the day of dosing.

Immunogenicity: Across clinical trials in patients aged ≥6 years receiving NUCALA, 6% developed anti-mepolizumab antibodies and 1 patient had neutralizing antibodies detected. The clinical relevance of anti-mepolizumab antibodies is not known.

NUCALA was also evaluated in a 4.5-year open-label safety and efficacy study.1

Red eosinophil Calculator

BLOOD EOSINOPHIL UNIT CONVERSION CALCULATOR

In asthma, an elevated EOS count is a sign that your patient may have eosinophilic asthma. Obtain an absolute eosinophil count in cells/µL from lab results to help decide if NUCALA is right for your patient.

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Getting patients started on NUCALA

GATEWAY TO NUCALA ENROLLMENT FORM

For biologic coordinators and other HCPs who help patients manage their NUCALA injection therapy: get resources right now to help them start and stay on NUCALA.

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