Elevated eosinophils play a key role in HES

 

Each patient with hypereosinophilic syndrome (HES) may present differently, and since HES is a rare disease (estimated prevalence of 5000 in the US*), it may be more difficult to diagnose.1,2 A thorough workup is essential for evaluating a patient who is presenting with hypereosinophilia.1 Below are some factors to consider when identifying patients with HES.

Defining hypereosinophilic syndrome3

Peripheral blood hypereosinophilia (>1500 cells/μL) on 2 exams (interval ≥1 month)

 

Eosinophil-mediated organ dysfunction and/or damage

 

Exclusion of other disorders as a major reason for organ damage

Clinical manifestations vary depending on organ involvement1,4

All HES patients are different. Patients may present with single- or multiple-organ involvement. Organs and organ systems that may be impacted by HES include:

Body diagram depicting organs and organ systems that may be impacted by hypereosinophilic syndrome (HES)
Body diagram depicting organs and organ systems that may be impacted by hypereosinophilic syndrome (HES)

 

*Estimate based on the National Hospital Discharge Survey of ~6000 discharges with at least 1 discharge diagnosis with the ICD code for eosinophilia; ~2000 cases were compatible with HES. The ratio of outpatients to inpatients (2.5:1) from a US claims database was applied to determine the final estimate.2

Diagnosis can be made immediately to avoid delay in therapy in the case of life-threatening organ damage.3

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Eosinophil reduction and mechanism of action (MOA)

See the results of NUCALA on eosinophil reduction

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Flare reduction

Proportion of patients with flares and time to first flare