NUCALA achieved and maintained normal eosinophil levels
Blood eosinophil count ratio to baseline
Baseline: 1460 cells/μL
reduction in eosinophils
at Week 32 vs placebo*
Week 32: 70 cells/μL
Results are descriptive. The clinical significance of these pharmacodynamic data is unknown.
Note: Mean normal blood eosinophil levels in a general population of subjects without confounding factors have been reported as 100 cells/µL (range: 34-257) and 107 cells/µL (5th, 95th percentile: 30, 395); levels vary based on age, sex, environmental exposures and comorbid conditions.3,4