IL-5 is the major cytokine responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils.
How NUCALA works to target eosinophils
NUCALA targets interleukin-5 (IL-5)
Role of eosinophils in maintaining health includes1:
- Regulating the immune system
- Tissue regeneration and repair
- Host protection (eg, defending against parasitic infection)
- Increased symptoms
- Greater likelihood for exacerbations
- Airway inflammation
Mean blood eosinophil levels5: 240 cells/µL at baseline; ~40-50 cells/µL on treatment.
Results are descriptive. The clinical significance of these pharmacodynamics data is unknown.